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Physiology I

Gmelinstraße 5
D-72076 Tübingen
phone: +49 (0)7071 29-72194
telefax: +49 (0)7071 29-3073

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Head of Department

Prof. Dr. med. Florian Lang





phone: +49 (0)7071 29-72194
fax: +49 (0)7071 29-5618
e-mail: florian.lang@uni-tuebingen.de


Sekretariat:
e-mail: physiol.loch@uni-tuebingen.de
phone: +49 (0)7071 29-72194



Research Interests


Research in the department focusses on properties and regulation of ion channels and transporters, cell volume regulation, suicidal cell death and host pathogen interaction. Scientist at the department come from more than a dozen countries and enjoy the free exchange of ideas, the joint efforts and the opportunity to pursue their goals with international cooperations.

Cell Size Matters

Erythrocyte death signaling

Serum-and Glucocorticoid inducible kinase isoforms

Studying Human Channels And Carriers In Frog Oocytes

The Role Of The Victim During Infection

The Suicide Machinery

Selected Publications

Kim MJ, Chae JS, Kim KJ, Hwang SG, Yoon KW, Kim EK, Yun HJ, Cho JH, Kim J, Kim BW, Kim HC, Kang SS, Lang F, Cho SG, Choi EJ
"Negative regulation of SEK1 signaling by serum- and glucocorticoid-inducible protein kinase 1."
EMBO J26p3075-85(2007)
Lang PA, Schenck M, Nicolay JP, Becker JU, Kempe DS, Lupescu A, Koka S, Eisele K, Klarl BA, Rübben H, Schmid KW, Mann K, Hildenbrand S, Hefter H, Huber SM, Wieder T, Erhardt A, Häussinger D, Gulbins E, Lang F
"Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide."
Nat Med13p164-70(2007)
Zhang W, Xia X, Reisenauer MR, Rieg T, Lang F, Kuhl D, Vallon V, Kone BC
"Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha."
J Clin Invest117p773-83(2007)
Lang F, Böhmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V
"(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms."
Physiol Rev86p1151-78(2006)
Vallon V, Grahammer F, Volkl H, Sandu CD, Richter K, Rexhepaj R, Gerlach U, Rong Q, Pfeifer K, Lang F
"KCNQ1-dependent transport in renal and gastrointestinal epithelia."
Proc Natl Acad Sci U S A102p17864-9(2005)
Huber SM, Uhlemann AC, Gamper NL, Duranton C, Kremsner PG, Lang F
"Plasmodium falciparum activates endogenous Cl(-) channels of human erythrocytes by membrane oxidation."
EMBO J21p22-30(2002)
Wulff P, Vallon V, Huang DY, Völkl H, Yu F, Richter K, Jansen M, Schlünz M, Klingel K, Loffing J, Kauselmann G, Bösl MR, Lang F, Kuhl D
"Impaired renal Na(+) retention in the sgk1-knockout mouse."
J Clin Invest110p1263-8(2002)
Lang F, Cohen P
"Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms."
Sci STKE2001pRE17(2001)
Grassmé H, Kirschnek S, Riethmueller J, Riehle A, von Kürthy G, Lang F, Weller M, Gulbins E
"CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa."
Science290p527-30(2000)
Lang F, Klingel K, Wagner CA, Stegen C, Warntges S, Friedrich B, Lanzendorfer M, Melzig J, Moschen I, Steuer S, Waldegger S, Sauter M, Paulmichl M, Gerke V, Risler T, Gamba G, Capasso G, Kandolf R, Hebert SC, Massry SG, Broër S
"Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy."
Proc Natl Acad Sci U S A97p8157-62(2000)
Grifa A, Wagner CA, D'Ambrosio L, Melchionda S, Bernardi F, Lopez-Bigas N, Rabionet R, Arbones M, Monica MD, Estivill X, Zelante L, Lang F, Gasparini P
"Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus."
Nat Genet23p16-8(1999)
Lepple-Wienhues A, Belka C, Laun T, Jekle A, Walter B, Wieland U, Welz M, Heil L, Kun J, Busch G, Weller M, Bamberg M, Gulbins E, Lang F
"Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids."
Proc Natl Acad Sci U S A96p13795-800(1999)
Hauck CR, Meyer TF, Lang F, Gulbins E
"CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway."
EMBO J17p443-54(1998)
Lang F, Busch GL, Ritter M, Völkl H, Waldegger S, Gulbins E, Häussinger D
"Functional significance of cell volume regulatory mechanisms."
Physiol Rev78p247-306(1998)
Szabò I, Lepple-Wienhues A, Kaba KN, Zoratti M, Gulbins E, Lang F
"Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes."
Proc Natl Acad Sci U S A95p6169-74(1998)
Wagner CA, Giebisch G, Lang F, Geibel JP
"Angiotensin II stimulates vesicular H+-ATPase in rat proximal tubular cells."
Proc Natl Acad Sci U S A95p9665-8(1998)
Grassmé H, Gulbins E, Brenner B, Ferlinz K, Sandhoff K, Harzer K, Lang F, Meyer TF
"Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells."
Cell91p605-15(1997)
Waldegger S, Barth P, Raber G, Lang F
"Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume."
Proc Natl Acad Sci U S A94p4440-5(1997)
Gulbins E, Szabo I, Baltzer K, Lang F
"Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases."
Proc Natl Acad Sci U S A94p7661-6(1997)
Brenner B, Gulbins E, Schlottmann K, Koppenhoefer U, Busch GL, Walzog B, Steinhausen M, Coggeshall KM, Linderkamp O, Lang F
"L-selectin activates the Ras pathway via the tyrosine kinase p56lck."
Proc Natl Acad Sci U S A93p15376-81(1996)
Busch AE, Schuster A, Waldegger S, Wagner CA, Zempel G, Broer S, Biber J, Murer H, Lang F
"Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions."
Proc Natl Acad Sci U S A93p5347-51(1996)
Rudel T, Schmid A, Benz R, Kolb HA, Lang F, Meyer TF
"Modulation of Neisseria porin (PorB) by cytosolic ATP/GTP of target cells: parallels between pathogen accommodation and mitochondrial endosymbiosis."
Cell85p391-402(1996)
van Kuijck MA, van Aubel RA, Busch AE, Lang F, Russel FG, Bindels RJ, van Os CH, Deen PM
"Molecular cloning and expression of a cyclic AMP-activated chloride conductance regulator: a novel ATP-binding cassette transporter."
Proc Natl Acad Sci U S A93p5401-6(1996)
Gulbins E, Coggeshall KM, Brenner B, Schlottmann K, Linderkamp O, Lang F
"Fas-induced apoptosis is mediated by activation of a Ras and Rac protein-regulated signaling pathway."
J Biol Chem271p26389-94(1996)
Busch A, Waldegger S, Herzer T, Biber J, Markovich D, Hayes G, Murer H, Lang F
"Electrophysiological analysis of Na+/Pi cotransport mediated by a transporter cloned from rat kidney and expressed in Xenopus oocytes."
Proc Natl Acad Sci U S A91p8205-8(1994)
Busch GL, Schreiber R, Dartsch PC, Völkl H, Vom Dahl S, Häussinger D, Lang F
"Involvement of microtubules in the link between cell volume and pH of acidic cellular compartments in rat and human hepatocytes."
Proc Natl Acad Sci U S A91p9165-9(1994)
Häussinger D, Roth E, Lang F, Gerok W
"Cellular hydration state: an important determinant of protein catabolism in health and disease."
Lancet341p1330-2(1993)
Lang F, Gerok W, Häussinger D
"New clues to the pathophysiology of hepatorenal failure."
Clin Investig71p93-7(1993)

Scientific Grants

IZKF Verbundprojektantrag 1466-0-0

Der PI3K/Akt-Signalweg in Pathogenese und Therapie von soliden Tumoren
Else Übelmesser Stiftung

Rolle des programmierten Erythrozytenzelltods bei der Zytostatika-induzierten Anämie
EU-LSHM-CT-2003-502852

European Genomics Initiative on Disorders of plasma membrane Amino acid Transporters
IZKF Promotionskolleg Molekulare Medizin
DFG-Hu 781/4-3

Schwerpunktprogramm: Intrazelluläre Lebensformen: (Lang/Huber) Ion channels and suicidal death of Plasmodium falciparum-infected erythrocytes
DFG-La 315/14-1

Kinasen in der Regulation von Transportprozessen der Zellmembran
DFG-La 315/13-2

Mechanismen und Regulation erythrocytärer Apoptose
DFG-La 315/11-2

Schwerpunktprogramm: Intrazelluläre Lebensformen: (Huber/Lang) Cell volume regulated ion channels in Plasmodium falciparum-infected erythrocytes
SFB/Transregio 19

Teilprojekt B5: Inflammatorische Kardiomyopathie - Molekulare Pathogenese und Therapie
DFG-Graduiertenkolleg GRK 1302/1

Der PI3K Signalweg bei Tumorwachstum und Diabetes
DFG-436 RUS 121/18/06 (R)

Pathophysiology of mental diseases

Official Positions

1992-today Head of the first Department of Physiology

1994-2002 Secretary and treasurer of the German Society of Nephrology

2000-2001 President of the German Physiological Society

2003-2004 Student Dean for preclinical studies

Managing editor of KIDNEY AND BLOOD PRESSURE RESEARCH and CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Associate editor of NEPHRON

Executive editor of PFLÜGERS ARCHIV

Member of the editorial board of the AMERICAN JOURNAL of PHYSIOLOGY/RENAL,

AMERICAN JOURNAL of PHYSIOLOGY/INTEGRATIVE and CELL PHYSIOLOGY, NEWS IN PHYSIOLOGICAL SCIENCES,

and JAPANESE JOURNAL OF NEPHROLOGY

   
 
 
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Last modified: 10.09.2009 11:54